Effect of Bone Marrow-Derived Mesenchymal Stem Cells and Nanoscaffold on Wound Healing in Irradiated Rats

Background: The effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) and nanoscaffolds were evaluated in enhancing wound healing irradiated albino rats. Methods: Sixty-four male rats subjected to 6 grays (Gy) gamma (γ)-rays. Surgical wounds created on the rats’ backs they randomly assigned one four groups (16 each); these an control group, which did not receive treatment, NS group treated with a nanoscaffold, BM-MSC injected subcutaneously 1 million BM-MSCs, combination BM-MSC+NS BM-MSCs nanoscaffold. Wound was measured clinically histologically. Results: greatest reduction anteroposterior dimensions recorded (-69.79 ±19.27), followed by (-61.12 ±17.32), then (-43.89 ±20.04), least decrease observed (-16.69 ±12.18) (p = 0.001). Meanwhile, lateral (-60.41 ±11.80), (-45.23 ±62.82), (-41.07 ±24.78), demonstrating (-16.49 ±20.90) 0.008). Histologically, demonstrated best results compared other groups. Conclusion: Nanoscaffolds and/or transplantation improved regeneration rats, providing possible therapeutic strategies for delayed during radiotherapy.